When the g.-131 C/G was used as a covariate to determine the influence of the remaining seven SNPs on serum concentrations of YKL-40 none of the other SNPs contributed significantly to the association supporting the isolated highly significant effect of the g.-131 C/G polymorphism on serum concentrations of YKL-40 (Table 4 ).
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Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects.
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