Few studies investigated the possible association between survivin and histological parameters or prognostic factors with controversial results: some of them reported no association between tissue and serum survivin expression and tumour size, p53 expression, oestrogen and progesteron receptors levels [ 162 – 164 ], while others showed that high-tissue survivin expression was correlated with high-nuclear grade, negative hormone receptor status and HER-2 over-expression [ 165 ], and that the presence of survivin is a highly significant independent predictor of shorter duration of survival in patients with poor prognostic features [ 166 ].
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