Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor.

The average score of the three raters was combined with the average score of the conservation and expression dynamics to arrive at a final ranking for the most interesting orphan genes for further study: the top genes are those for which we have absolutely no information about their function, that are ultra-highly conserved across species, and show a highly significant dynamics in their gene expression (Table 1 ).

also in 132,142 other papers