Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.

Mol Biol Cell · 2011 · PMC3226483 · PMID 21976700

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an overall trendno p-value reported

In MMS-treated cells, there was also an overall trend of reduced enrichment of Smc5/6 at lesion-containing loci in nse2-SA nse1-C216S cells, although the largest reduction was seen at tRNA Leu and the subtelomeric repeats (Ste1), which corresponds to the regions of Smc5/6 enrichment at a global genomic level ( Pebernard et al. , 2008b ).

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