A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain.

Adv Pharmacol Sci · 2011 · PMC3226534 · PMID 22162674

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a nonsignificant trendno p-value reported

Our preclinical qEEG data correlate well with the reported in vitro activity of the two compounds and to some extent mimic the effects observed in our preclinical pain models, with L-838,417 exhibiting a significant change in beta frequency in a dose-related fashion, but TPA023 exhibiting a nonsignificant trend to increase.

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