Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks.

Aging (Albany NY) · 2011 · PMC3227452 · PMID 22025769

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highly significantno p-value reported

Overall, methylation patterns of MSC were maintained throughout both long-term culture and aging whereas highly significant modifications occur at specific CpG sites.

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