Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis.

Interestingly, the larger cluster shows a highly significant accumulation of genes involved in DNA replication, nucleotide metabolism, cell cycle regulation and DNA damage response ( Fig. 3B ), which were also found in the smaller cluster (here significance of accumulation was not reached because of the small number of genes).

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