Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts.

The present study also suggests that beyond the local regulation of SZ expansion, this process can also be regulated at longer-range levels, manifested here by the rare, but highly significant capability of SZ to bypass the inhibitory action of narrow barriers ( Fig. 5 ), suggesting that the interconnecting actin fibers can extend beyond the confines of the podosome contours [21] , enabling them to reach close to the ventral membrane, beyond the passivated region and link to podosomes located at these regions, practically offering an inside-out linkage.

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