Fredenburg 1 demonstrated a highly significant increase in patency time for catheters with rounded tips (mean 27.8 days) vs blunt tip catheters ( Fig. 2 ) (mean 19.9 days) without rinsing, whereas a lock solution was not of significant influence on patency.
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Pathology in Continuous Infusion Studies in Rodents and Non-Rodents and ITO (Infusion Technology Organisation)-Recommended Protocol for Tissue Sampling and Terminology for Procedure-Related Lesions.
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