Haplotype analysis revealed that a haplotype of CRHR1had a highly significant positive association with recurrent MDD, a haplotype with alleles G-G-T respectively the SNPs of rs1876828, rs242939, rs242941, was significantly over represented in the recurrent MDD group than in the control group (chi-2 = 10.059, df = 1, P = 0.016), which suggested that carrying this haplotype might increase the probability of developing recurrent MDD in Han Chinese population.
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Interaction between CRHR1 and BDNF genes increases the risk of recurrent major depressive disorder in Chinese population.
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