SACK-expanded hair follicle stem cells display asymmetric nuclear Lgr5 expression with non-random sister chromatid segregation.

This highly significant difference in self-renewal pattern (p < 0.0004; two-tailed Fisher's exact test) is consistent with nuclear Lgr5 marking HF-SCs that shift between symmetric self-renewal and asymmetric self-renewal in response to Xn.

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