Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro.

However, high SFA concentration led to a highly significant increase in NFκB expression in the adipose tissue explants in the presence of L- and H-Glc ( P <.001 and P <.001 respectively; Fig. 2C and 2D ). 3.3 Effects of chronic treatment with SFA and glucose on JNK1 and JNK2 protein expression No statistically significant differences in treatments were obse

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Similarly, MyD88 adaptor protein expression increased with all combinations of Glc and SFA in explants and adipocytes, excluding L-Glc combined with low and high SFA, respectively, in adipocytes — although the latter was close to significance at P =.055 ( Fig. 4C and 4D ).

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