GSEA of genes associated with these pediatric molecular groups of T-ALL ( Ferrando et al., 2002 ) against the two clusters of adult T-ALLs identified in our series showed a highly significant enrichment of LYL1 /immature T-ALL–associated genes in cluster I, whereas cluster II was associated with TLX1 /early cortical and TAL1 /late cortical T-ALL signatures ( Fig. 1 C ).
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