Development of an antibody to bovine IL-2 reveals multifunctional CD4 T(EM) cells in cattle naturally infected with bovine tuberculosis.

PLoS One · 2011 · PMC3245252 · PMID 22216206

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highly significantno p-value reported

IL-2 showed a highly significant increase in MFI in the IFN-γ + TNF-α + and triple producers (ρ<0.001).

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an overall trendno p-value reported

Thus, the expression of IFN-γ, IL-2 and TNF-α was significantly greater in the multifunctional (double & triple) populations that in any of the mono-functional populations and there was an overall trend of higher quality of response as the cells increased in function.

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