Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran.

Thus, overall, there was a highly significant association between the presence of missense mutation and p53 expression scores ( p <0.001), and there was a strong association between nonsense/splice/frameshift mutations and lack of p53 expression ( p = 0.013/ p = 0.005/ p = 0.018 respectively).

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