The defined cut off values have been based on previous cohort data which identified patients with moderate to severe proteinuria at greater risk of poor renal outcome [22] , [24] and so we require all patients with a UACR between 100–200 mg/mmol with an increasing trend and those with a UACR>200 mg/mmol to immediately exit from the pathway for further investigation and management in liaison with a paediatric nephrologist.
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