A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis.

PLoS Comput Biol · 2012 · PMC3252265 · PMID 22241976

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likely to be significantno p-value reported

The order of PTEN and CDK4 determined for samples belonging to the proneural subtype, however, passed the threshold of 58% flux through the network and also had a p-value for correlation of 0.02, and was therefore more likely to be significant.

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