MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemias.

Indeed, we found a highly significant inverse correlation between miR-146a expression and CXCR4 membrane protein level, indicative of a posttranscriptional control of gene expression; in fact, the plotting of miR-146a and CXCR4 protein levels showed that these two parameters are inversely related ( r 2 =0.45; P =0.0001) ( Figure 1d ).

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