Barely Significant
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Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly.

Aging Cell · 2012 · PMC3257374 · PMID 22023165

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The sentences

highly significantP < 0.0001actually significant
Using a multivariable mixed effect model, we report a highly significant increase in TLR5-induced production of IL-8 from monocytes of older individuals ( P < 0.0001).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.