Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation.

Several observations support the significance of the methylation peaks at CpG site 5 in both strands: (i) P -values are highly significant (except for the comparison of site 5 and 6 in the lower strand where the P -value is 0.078) ( Supplementary Figure S4 ), (ii) the geometry of the peaks is palindromic in the upper and lower strand with methylation peaks at sites 2, 3 and 5 in the upper strand corresponding to methylation peaks at s

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