HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells.

Although we observed a decreasing trend in T-cell proliferation stimulated by IDC exposed to HIV-1 ( Fig. 2A and B ), their inherent decreased capacity to activate T cells and ability to suppress T-cell responses [ 27 ] masked any significant inhibition caused by HIV-1 exposure.

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