Their randomized, open-label trial revealed a positive trend for IVIg after 6 weeks. 6 One large, randomized, placebo-controlled trial conducted in patients with worsening weakness produced the promising finding that IVIg improved muscle strength (class I evidence). 7 Two randomized controlled trials found no significant difference between the efficacies of IVIg and PE, although IVIg therapy was less toxic. 8 , 9 Accordingly, it has been accepted that while their treatment efficacies are similar, IVIg is a safer option than PE.
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