Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance.

We observed that the mRNA levels of PPARα and the PPARα-regulated genes CPT-1a, ACOX1, LCAD, Uncoupling protein 2 (UCP2) and UCP3 were elevated or exhibited an increasing trend in the adipose tissue, as well the mRNA expression of PPARα, CPT-1a, ACOX1, LCAD and UCP3 were markedly increased in the skeletal muscle ( Fig. 4A, B ).

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