Analysis of the joint effect of the original 10 as well as the statistically significant 7 SNPs (rs2981582, rs3803662, rs889312, rs13387042, rs13281615, rs3817198 and rs981782) found a highly significant trend for increasing breast cancer risk with increasing number of risk alleles ( P -trend 5.6 × 10 −20 and 1.5 × 10 −25 , respectively).
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The sentences
For SNP rs1045485 in CASP8, originally discovered by Cox et al (2007 ) through candidate gene analysis, we found a similar point estimate as in the original study for women >50 years of age, although the association with breast cancer did not achieve significance in our cohorts.