Negative epistasis between α+ thalassaemia and sickle cell trait can explain interpopulation variation in South Asia.

Evolution · 2011 · PMC3263337 · PMID 22133230

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might be significantno p-value reported

In the specific case of the Koya Dora of AP, it might be significant that 10% of alpha thalassaemia in this population is due to a unique mutant of the normal α chain termination codon, dubbed HbKD ( De Jong et al. 1975 ).

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