Recent insights into the involvement of progranulin in frontotemporal dementia.

Curr Neuropharmacol · 2011 · PMC3263457 · PMID 22654721

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highly significantno p-value reported

In follow-up studies, an association analysis demonstrated a highly significant correlation between TMEM106B and PGRN plasma levels and mRNA expression, with greater statistical significance in patients with FTLD with GRN mutations [ 80 ]; these results suggested that TMEM106B expression modulates the development of FTLD through its interactions with PGRN.

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