highly significantP = 0·00025
Importantly, while the BV/TV values of sham-operated wild-type and PLCγ2 −/− animals were statistically highly significant ( P = 0·00025), there was no significant difference between the two genotypes after the ovariectomy procedure ( P = 0·25; n = 7 (wild type) vs. 4 (PLCγ2 −/− )).