Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults.

BMC Med Genet · 2011 · PMC3270002 · PMID 21884617

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a statistical trendno p-value reported

A p-value < 0.05 was considered statistically significant; a p-value between 0.05 and 0.1 as an indicator for a statistical trend of significance.

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borderline significanceno p-value reported

Except for a borderline significance found for the enrichment of 158Val alleles with MB-COMT promoter hypomethylation and disease disposition, there was however no consistent relation between individual epigenotype and the Val158Met polymorphism.

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highly significantno p-value reported

In blood derived DNA, we found highly significant associations of methylation levels with each of the analyzed genotypes (table 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.