BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis.

A highly significant increase in TNF-α-induced NF-κB transcriptional activity was detected in HCT116 cells when BAG-1S was fused to a NLS when compared to BAG-1S fused to a NES ( figure 1B ), despite the fact that expression of the BAG-1SNES protein was higher than the BAG-1SNLS protein ( figure 1C ).

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