Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.

Nat Commun · 2012 · PMC3272577 · PMID 22215083

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highly significantno p-value reported

Both strains faithfully mimic the systemic accelerated ageing of XFE progeroid syndrome and demonstrate a highly significant correlation with naturally aged mice at the level of histopathology, pathophysiology and genome-wide transcriptional reprogramming 30 , 32 , 33 , 34 .

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