Determining PTEN functional status by network component deduced transcription factor activities.

c-MYC target genes BCAT1 , CDK4 , EIF4E , and SHMNT1 were selected because (1) their proximal promoter regions contain c-MYC consensus binding sequence (CACGTG), which is conserved between human and mouse; and (2) the control strengths by c-MYC were highly significant based on NCA analysis ( Figure 1C ).

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The prostate cancer-related TFA signatures can be used to classify PTEN status in human prostate cancers to a similar accuracy as the PTEN-controlled TFAs, but they had less cross-tissue predictive power as they failed to reach significance levels when applied to breast and brain tumors ( Figure 5B , blue bars).

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