Integrating Rare-Variant Testing, Function Prediction, and Gene Network in Composite Resequencing-Based Genome-Wide Association Studies (CR-GWAS).

There was highly significant non-independence ( P-value = 1.8 × 10 −34 ) between the two predictions, driven primarily by the large proportion (66%) of SNPs predicted to be benign by PolyPhen and tolerant by SIFT.

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