Context-dependent effects of a single administration of mirtazapine on the expression of methamphetamine-induced conditioned place preference.

This effect is highly significant because it indicates that Meth contributes to the labile state induced by contextual cues to promote the pharmacological actions of mirtazapine and demonstrates that activation of brain regions by re-exposure to salient cues and by Meth administration synergize to render the brain susceptible to influence by mirtazapine.

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