Effects of combined deferiprone with deferoxamine on right ventricular function in thalassaemia major.

Comparing the individual treatment arms, we observed a significant improvement in RVEF in patients with T2* between 8 and 12 ms on combination therapy (58.5 ± 6.9% at baseline vs 63.3 ± 6.0% at 12 months, p < 0.01), and borderline significant improvement in patients with T2* between 12 and 20 ms (62.1 ± 7.3% at baseline vs. 64.3 ± 6.0% at 12 months, p = 0.08).

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Despite a positive trend, neither cardiac medication as a whole (increase RVEF 12 ± 6% vs 9 ± 5%, p = 0.2), nor individual medications (digoxin: 14 ± 3% vs 10 ± 6%, p = 0.2; ACEi/ARB: 12 ± 6% vs 9 ± 5%, p = 0.2; diuretics: 13 ± 5% vs 10 ± 6%, p = 0.4) were significantly associated with a higher increase in RVEF compared with those without cardiac medication.

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