Carbohydrate restricted diet in conjunction with metformin and liraglutide is an effective treatment in patients with deteriorated type 2 diabetes mellitus: Proof-of-concept study.

In a multilevel model describing HbA1c as dependent variable, the predictor time was highly significant at all time points (p < 0.0001), using time as categorical variable (drop of HbA1c at: Visit 4 = -2.3308, Visit 3 = -2.3583, Visit 2 = -2.0816, Visit 1 = -1.2916) or as continuous variable (drop of HbA1c per time unit = -0.5964).

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The addition of gender to the model showed no significant effect, but adding insulin resulted in a marginally significant interaction term time*insulin -0.2255 (p = 0.047).

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