Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel.

Discussion In this first study evaluating histone modifications in relation to occupational Ni exposure in refinery workers and to human urinary Ni levels, we found highly significant elevated levels of H3K4me3 modification in Ni-exposed workers and in subjects with greater urinary Ni, consistent with previous studies reporting that exposure to Ni increases global levels of H3K4me3 in vitro ( Zhou et al. 2009 ).

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