Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.

LY294002- (an Akt inhibitor, used as a positive control) and DHC-treated HUVECs over-expressing Akt exhibited a highly significant increase in the expression of cyclin D1 relative to the vector-treated group ( Figure 5C ).

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