Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.

Mol Cancer · 2012 · PMC3281783 · PMID 22216762

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highly significantno p-value reported

The CASP8AP2/FLASH RNAi signature shows broad deregulation of histone gene transcription The most intriguing aspect of the CASP8AP2/FLASH RNAi signature was the highly significant enrichment (normalized enrichment score = 2.53; FDR q-value < 0.001) for histone transcripts (Figure 5A ).

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