Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production.

Prophylactic treatment with 2 g/kg of IVIg ip 18 hours before the induction of acid-induced ALI showed a slight trend towards an attenuated injury response in that the decline in SaO 2 subsequent to acid instillation was largely blocked, yet no significant differences in peak inspiratory pressures or mouse W/D lung weight ratios were detectable between saline and IVIg pretreated mice ( Figure 8 ).

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