Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation.

It was also observed that the area under the curve (AUC 0–120 hours ) of SMEDDS was 73.59 ± 31.21 μg · mL −1 · hour, and thus the difference was highly significant compared with that of the oil solution (34.16 ± 10.65 μg · mL −1 · hour) ( P < 0.02) and suspension (7.20 ± 1.63 μg · mL −1 · hour) ( P < 0.001).

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