Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.

PLoS Med · 2012 · PMC3283559 · PMID 22363213

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highly significantno p-value reported

Previous meta-analyses just of the published studies [6] , [10] – [12] have found, in aggregate, a highly significant but only moderately positive association of MTHFR genotype with CHD risk (odds ratio [OR] for TT versus CC genotype of 1.16 in the most recent report [6] ), but opinions differ as to whether publication bias could explain away this aggregate result [6] , [10] – [12] .

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