Association of mitochondrial DNA variations with lung cancer risk in a Han Chinese population from southwestern China.

Distribution of the 822 bp mtDNA deletion among cases and controls When the subjects from both cases and controls were pooled and stratified by median number of pack-years of combined cases and controls, a subsequent linear-by-linear association test revealed an increasing trend for mtDNA deletion from non-smoking to heavy smoking groups (both p value and p trend <0.001) ( Fig. 2A ).

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