Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea.

J Am Chem Soc · 2012 · PMC3284192 · PMID 22280147

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a slight trendno p-value reported

Indeed, a slight trend to larger “ m -values” of TMAO in the presence of urea has been observed 20 ( m -values are a measure of how potent an osmolyte is in stabilizing a protein).

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