Barely Significant
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Opposite effects of tissue inhibitor of metalloproteinases-1 (TIMP-1) over-expression and knockdown on colorectal liver metastases.

BMC Res Notes · 2012 · PMC3284431 · PMID 22230683

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highly significantno p-value reported
Indeed, the knockdown of endogenous murine TIMP-1 led to a dramatic and highly significant increase of tumor burden.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.