Three "hotspots" important for adenosine A(2B) receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop.

Purinergic Signal · 2012 · PMC3286537 · PMID 21818573

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may be significantno p-value reported

This results in a reduced interface between helix 4 and 5 that may be significant in the activation process [ 30 ].

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