Analysis of adverse events and quality of life data for an economic evaluation of adjuvant chemotherapy in colorectal cancer: when can we stop collecting?

Uni- and multivariate regressions were re-run using indicator variables for AE grade groups for each specific adverse event type, and showed a highly significant (1% level) negative impact on quality of life as severity of grade increased, particularly for the adverse events Diarrhoea (-0.04 grade 1/2, -0.09 grade 3/4), Fatigue (-0.02 grade 1/2), Nausea (-0.05 grade 1/2, -0.14 grade 3/4), Neuropathy sensory (-0.02 grade 1/2, -0.19 grade 3/4), and Vomiting (-0.05 grade 1/2).

also in 132,142 other papers