Stratify or adjust? Dealing with multiple populations when evaluating rare variants.

However, if 50 replicates were meta-analyzed, PRKCA became significant in the Asian sample ( N = 16,050, p = 3.4 × 10 −11 ) and in the Yoruba sample ( N = 5,600, p = 5.6 × 10 −9 ) and was trending toward significance in the Luhya sample ( N = 5,400, p = 4.3 × 10 −5 ).

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Finally, although our top signal in each analysis result was a true signal, there were many more highly significant false positives than we would have expected.

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