Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population.

After multivariable logistic regression analysis, only the NOD2 SNPs (rs2066844, rs2066845, and rs5743293) remained highly significant predictors of disease ( p < 0.001), and in this context all were descriptive of CD, in agreement with previous reports.

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Although only one IL23r SNP was marginally significant in our univariate analysis, another variation of this allele yielded notable results when present with a NOD2 variant.

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