The contrasting relationships between betaine and homocysteine in two clinical cohorts are associated with plasma lipids and drug treatments.

A highly significant effect was seen with subjects treated with angiotensin II receptor antagonists; there were too few of these to analyse the data in the same way, but in the group of all subjects without diabetes being treated with these drugs (n = 24) the correlation between log(urine betaine excretion) and log(plasma homocysteine), Pearson's r = +0.77 (p = 0.00001); if subjects with diabetes are included (n = 34), r = +0.44 (p = 0.009).

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In ACS subjects with above median betaine excretion a positive trend (r = +0.10) between betaine excretion and homocysteine was not significant; the corresponding correlation in lipid clinic subjects was r = +0.42 (p = 0.0001).

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