Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles.

Mol Ther · 2012 · PMC3293602 · PMID 22252449

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highly significantno p-value reported

As shown in Figure 4b the reduction in the monomer pool 3 months after miRNA is evident in all the groups, densitometric analysis of the bands shows highly significant differences in the PolyA -3XmiR and Double -6XmiR as compared to mice treated with a GFP vector control( Figure 4c ).

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